Senior Computational Biologist

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About the role:

We are currently looking for a Senior Computational Biologist within the Clinical and Experimental Pharmacology Group (CEP) and the newly established Manchester Centre for Cancer Biomarker Sciences (MCCBS). One aspect of this team’s role will be to evaluate data from DNA and/or RNA derived from patient blood samples to derive robust classifiers.  Pivotal goals of the Centre are to develop biomarker signatures to improve cancer detection, to aid prognosis and to predict patient response to therapy with an overall goal to facilitate the personalised medicine approach.   The flagship project of the MCBBS is TARGET, a clinical protocol in which Phase I clinical trial patients provide a blood sample at baseline. We are asking whether analysis of their ctDNA can assist in selection of the best clinical trial available for each patient. Bioinformatics analysis of TARGET derived clinical samples will be the first priority for this post holder. 

The aim of this post is to contribute to the success of translational research aimed at next generation sequencing (NGS) of nucleic acids obtained from patient blood samples.  The overall goal of this project is to identify information that can be used to optimise cancer patient treatment selection.

About you:

You should have a degree in computational biology, mathematics or related discipline (or equivalent) plus significant relevant experience analysing genomics data or a relevant postgraduate degree. Additionally you should have substantial experience writing complex code in at least one of the following: Perl, Python, R, Matlab, C, or C++.

Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute (, an Institute of The University of Manchester (, is a world-leading centre for excellence in cancer research.  The Institute is core funded by Cancer Research UK (, the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.

We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK MI Paterson Building) in South Manchester (, one of the largest cancer treatment centres in Europe.  These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

How to apply?

To apply for this position please visit our website:

For any informal enquiries about this position please contact Dr Ged Brady via email: [email protected].

Closing date: Sunday 9 December 2018.

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